

Prions:
Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders. Prions a disease causing agent that is neither bacterial nor fungal nor viral and contains no genetic material.

Viroids:
Viroids are infectious agents composed exclusively of a single piece of circular single stranded RNA which has some double-stranded regions.Because of their simplified structures both prions and viroids are sometimes called subviral particles. Viroids mainly cause plant diseases but have recently been reported to cause a human disease
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